Polynucleotides are injectable skin boosters that regenerate tired skin using purified DNA fragments. They work at the cellular level to stimulate collagen, improve hydration, and reduce fine lines. Safe and effective, they’re especially helpful under the eyes. Available now at Exthetics in Exeter, with natural results that last up to 9 months.

If your skin feels dull, crepey, or just plain tired, you’re not alone. Many people in their 30s, 40s, and 50s start to see changes in their skin. They may notice fine lines, wrinkles, dark circles, less firmness, and uneven tone.

Polynucleotides in Exeter: Regeneration for Tired Skin

At Exthetics in Exeter, we now offer polynucleotide treatments. This is a new injectable treatment that helps regenerate and rejuvenate at the cellular level.

Polynucleotides are becoming a popular skin booster in UK clinics. They not only improve tired skin’s appearance but also help it heal from within. This guide will walk you through how they work, what to expect, and why this injectable bio stimulator could be right for you.

What Are Polynucleotides?

Polynucleotides are purified DNA fragments, typically derived from salmon or trout, that mimic your body’s own genetic material. Once injected, these fragments help your skin heal. They boost collagen and elastin production, increase hydration, and lower inflammation.

Polynucleotides are different from dermal fillers and anti-wrinkle injections. Dermal fillers add volume, while anti–wrinkle injections relax muscles. Polynucleotides help your skin start its natural repair processes. This makes them ideal for improving skin quality without altering your facial structure.

Key Polynucleotide benefits include:

Improves skin texture and elasticity
Helps with stretch marks, scarring, and sun damage
Reduces fine lines and wrinkles
Brightens dark circles under the eyes
Supports recovery from sensitivity or inflammation

What to Expect from Polynucleotide Treatment in Exeter

At Exthetics, your journey starts with a full clinical consultation. We assess your skin condition, discuss your goals, and determine if polynucleotide treatments are right for you and your skin goals.

During your treatment:

We apply a numbing cream before using fine needles or microneedling the solution into the skin
Target areas may include under-eyes, cheeks, neck, or décolletage
You may experience some redness, swelling, or mild bruising post-treatment
Sessions take about 30 minutes, with 2–3 treatments spaced 2–4 weeks apart

We may also combine polynucleotides with other treatments like hyaluronic acid skin boosters, microneedling, or radiofrequency microneedling for enhanced results.

How Polynucleotides Work and When to Expect Results

This treatment doesn’t deliver instant volume like filler – instead, it builds skin health at the cellular level over time.

Typical results timeline:

Week 1–2: Reduction in dryness and dullness
Week 3–4: Noticeably smoother texture, brighter tone
Week 8–12: Peak production of collagen and elastin, visible softening of fine lines and wrinkles
6–9 months: Results maintained with a top-up session

Patients often see the most visible transformation under the eyes, where dermal fillers can sometimes look puffy or unnatural. Polynucleotides deliver more natural, tissue-supporting outcomes.

Are Polynucleotides Safe?

Yes! Polynucleotide treatments are well-tolerated and come with a strong safety record when performed by qualified professionals.

Derived from sterile, medical-grade DNA fragments
Biocompatible and broken down safely by the body
Anti inflammatory properties make them suitable for sensitive skin
Minimal downtime – just mild redness, swelling, or bruising in the treated areas

We don’t recommend this treatment during pregnancy, breastfeeding, or for anyone with a fish allergy.

Who Should Consider Polynucleotides?

This treatment is ideal for anyone looking to improve skin health naturally, especially those who want:

Smoother, stronger skin without added volume
Help with dark circles, crepey under-eyes or stretch marks
Relief from inflammation or signs of environmental stress
To build collagen over time without harsh resurfacing

If you are not ready for dermal fillers or want a natural option, this could be the perfect skin booster for you.

Polynucleotides vs Other Injectable Treatments

Treatment	Hydration	Collagen Boost	Volume	Under-Eye Safe
Polynucleotides	Yes	Yes	No	Yes
Hyaluronic Acid Boosters	Yes	Limited	No	Varies
Dermal Fillers	No	No	Yes	Varies
Anti Wrinkle Injections	No	No	No	Yes

Why Choose Exthetics for Polynucleotides in Exeter?

Exthetics is proud to be a top aesthetic clinic. We offer injectable bio stimulators, like polynucleotides, in Exeter, Devon.

Here’s why local clients trust us:

Qualified medical team: Led by nurse prescriber Anna Lee
Skin-first philosophy: We treat your skin, not trends
Advanced diagnostics: OBSERV 520X scan at every consultation
Tailored plans: We often combine polynucleotides with Profhilo or RF for long-term improvement
Trusted brands: We use Plinest, known for safety and results

If you’re looking to improve your skin health in Exeter, we’d love to guide your next step.

Book Your Consultation for Polynucleotides in Exeter

If your skin feels tired, loose, or dull, especially around the eyes, polynucleotides might be what you need. This natural injectable treatment helps repair skin without adding volume or using harsh ingredients. It is ideal for patients who want safe, long-lasting results.

Book your personalised consultation at Exthetics in Exeter today. Discover how this advanced skin booster can help you feel like yourself again, but fresher.

What do polynucleotides do to your skin?

They stimulate skin regeneration by promoting collagen and elastin production at a cellular level. This leads to smoother, brighter, and more hydrated skin over time.

Are polynucleotides better than Botox?

Different tools: Botox relaxes muscles to smooth lines. Polynucleotides rebuild collagen and hydration for better skin texture, as shown in our comparison table above. Many clients combine both.